tBuLi‐Promoted Intermolecular Regioselective Nucleophilic Addition of Arenes to Diazo Compounds as N‐Terminal Electrophiles: Efficient Synthesis of Hydrazine Derivatives,European Journal of Organic Chemistry

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tBuLi‐Promoted Intermolecular Regioselective Nucleophilic Addition of Arenes to Diazo Compounds as N‐Terminal Electrophiles: Efficient Synthesis of Hydrazine Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-11-06 , DOI: 10.1002/ejoc.201700864
Lu Zhang ₁ , Xiang-He Meng ₁ , Pei Liu ₁ , Jie Chen ₂ , Yu-Long Zhao ₁

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The tBuLi‐promoted intermolecular nucleophilic addition of arenes to diazo compounds as the N‐terminal electrophiles has been developed. This reaction is regioselective and not only provides an efficient method for aromatic C–N bond formation under transition‐metal‐free and oxidant‐free conditions but also represents a strategy for the 3‐amination of pyridines and the dearomatization of indoles.

中文翻译：

tBuLi促进芳烃向重氮化合物作为N端亲电体的分子间区域选择性亲核加成反应：肼衍生物的高效合成

已经开发出由t BuLi促进的芳族分子间亲核加成到重氮化合物上的N端亲电体。该反应具有区域选择性，不仅为在无过渡金属和无氧化剂的条件下形成芳族C–N键的有效方法，而且代表了吡啶3胺化和吲哚脱芳香化的策略。

更新日期：2017-11-06

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