Genotype-defined resistance to antiretrovirals supposedly predicts future virological failure. Findings from clinical studies, including the 144 week results from the EARNEST trial, published in The Lancet Infectious Diseases,¹ challenge this decades-long dogma, certainly when it comes to nucleoside analogues.

中文翻译：

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NRTIs在二线治疗中出乎意料的成功

基因型定义的抗逆转录病毒药耐药性可以预测未来的病毒学失败。临床研究的发现，包括发表在《柳叶刀传染病》上的EARNEST试验的144周结果，[ ^1]挑战了长达数十年的教条，当然是关于核苷类似物的挑战。