Harzianols A−E (2–6) and harziane acid (7), six new oxidized derivatives of harzianone (1), were obtained from the microbial transformation by a bacterial strain Bacillus sp. IMM-006. The structures of these products, including the stereochemistry, were elucidated by extensive spectroscopic analysis. The absolute configuration of 2 was unambiguously determined by single-crystal X-ray diffraction. Moreover, a plausible bioconversion pathway was proposed.

中文翻译：

---

芽孢杆菌（Bacillus sp。）对哈氏酮的微生物氧化。IMM-006

Harzianols A-E（2–6）和harziane酸（7），是六个新的harzianone氧化衍生物（1），是通过细菌菌株Bacillus sp。的微生物转化而获得的。IMM-006。通过广泛的光谱分析阐明了这些产物的结构，包括立体化学。通过单晶X射线衍射明确地确定2的绝对构型。此外，提出了一个可行的生物转化途径。