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Asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a diaminomethylenemalononitrile organocatalyst
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-04 , DOI: 10.1016/j.tetlet.2017.10.078 Hiroshi Akutsu , Kosuke Nakashima , Shin-ichi Hirashima , Moeko Kitahara , Yuji Koseki , Tsuyoshi Miura
中文翻译:
使用二氨基亚甲基丙二腈有机催化剂将5-苄基糠醛不对称共轭加成至硝基烯烃
更新日期:2017-11-04
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-04 , DOI: 10.1016/j.tetlet.2017.10.078 Hiroshi Akutsu , Kosuke Nakashima , Shin-ichi Hirashima , Moeko Kitahara , Yuji Koseki , Tsuyoshi Miura
A pyrrolidine–diaminomethylenemalononitrile organocatalyst efficiently promotes the asymmetric direct bisvinylogous Michael addition of 5-benzylfurfural derivatives to nitroalkenes, affording the corresponding ε-regioselective addition products in high yields with up to 86% ee.
中文翻译:
使用二氨基亚甲基丙二腈有机催化剂将5-苄基糠醛不对称共轭加成至硝基烯烃
吡咯烷-二氨基亚甲基丙二腈有机催化剂有效地促进了5-苄基糠醛衍生物向乙烯基烯类的不对称直接双乙烯基迈克尔双加成反应,从而以高收率提供了相应的ε-区域选择性加成产物,ee高达86%。