An efficient and scalable route for the synthesis of nitriles was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with NH₄OAc. A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which is the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling.

中文翻译：

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乙酰胺与乙酸铵合成乙氧基铵盐介导的氧化腈

通过氧铵盐（4-乙酰氨基-2,2,6,6-四甲基哌啶-1-氧代四氟硼酸铵）介导的醛与NH ₄ OAc的氧化反应，开发了一种高效且可扩展的腈合成路线。各种脂族醛和苯甲醛均以高收率转化为相应的腈。通过简单的酸碱萃取回收作为用过的氧铵盐的还原物种的硝酰自由基，以进行再循环。