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Total Synthesis of (−)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-02 00:00:00 , DOI: 10.1021/acs.orglett.7b03133
Yu Zheng 1, 2 , Kun Wei 1 , Yu-Rong Yang 1
Affiliation  

The iridium-catalyzed, Zn(OTf)2 promoted asymmetric allylic amidation of a secondary alcohol derived from tryptamine has been utilized to forge a tetrahydro-β-carboline. Based on this key step, a novel, facile, and enantioselective total synthesis of (−)-geissoschizol was achieved in 10 steps.

中文翻译:

以Ir催化的烯丙基酰胺化为关键的(-)-Geissoschizol的全合成。

铱催化的Zn(OTf)2促进的不对称烯丙基酰胺化衍生自色胺的仲醇已被用于伪造四氢-β-咔啉。基于该关键步骤,分十步完成了新颖,简便,对映选择性的(-)-geissoschizol合成。
更新日期:2017-11-02
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