Total Synthesis of (−)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Total Synthesis of (−)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-02 00:00:00 , DOI: 10.1021/acs.orglett.7b03133
Yu Zheng _{1,

2} , Kun Wei ₁ , Yu-Rong Yang ₁

Affiliation

The iridium-catalyzed, Zn(OTf)₂ promoted asymmetric allylic amidation of a secondary alcohol derived from tryptamine has been utilized to forge a tetrahydro-β-carboline. Based on this key step, a novel, facile, and enantioselective total synthesis of (−)-geissoschizol was achieved in 10 steps.

中文翻译：