After a chemical screening of subtidal sponges from the Northeastern Atlantic, Clathria (Microciona) strepsitoxa (Poecilosclerida: Microcionidae) was selected for deeper investigation. This first chemical study led to the identification of two new 8-oxoisoguanosine derivatives. The structure elucidation was performed after extensive analyses of spectroscopic (1D and 2D NMR) and HR-ESIMS data and no significant antimicrobial or cytotoxic activity was detected.

中文翻译：

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东北大西洋海绵棘（Microciona）strepsitoxa的异鸟苷衍生物

在对东北大西洋的潮间带海绵进行化学筛选后，选择了钩枝纲（Microciona）链霉菌（Poecilosclerida：Microcionidae）进行更深入的研究。这项第一项化学研究导致鉴定出两个新的8-氧代异鸟苷衍生物。在对光谱（1D和2D NMR）和HR-ESIMS数据进行了广泛分析之后，进行了结构鉴定，未检测到明显的抗微生物或细胞毒性活性。