To the Editor With interest, we read the report by Chu and colleagues¹ investigating the association of proton pump inhibitors (PPIs) with capecitabine efficacy in patients with advanced gastroesophageal cancer. This retrospective analysis revealed a significant difference in treatment efficacy in patients treated with capecitabine and oxaliplatin with and without concomitant PPI use, probably due to an increased intragastric pH and subsequent impaired capecitabine absorption.

中文翻译：

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影响质子泵抑制剂与卡培他滨在晚期胃食管癌中疗效关联的因素。

致编辑我们感兴趣地阅读了 Chu 及其同事¹的报告，该报告调查了质子泵抑制剂 (PPI) 与卡培他滨对晚期胃食管癌患者疗效的关系。这项回顾性分析显示，卡培他滨和奥沙利铂联合使用或不联合使用 PPI 的患者的治疗效果存在显着差异，这可能是由于胃内 pH 值升高和随后卡培他滨吸收受损所致。