The FOXFIRE, SIRFLOX, and FOXFIRE-Global studies investigated the efficacy of combining first-line chemotherapy for metastatic colorectal cancer with selective internal radiotherapy (SIRT) using yttrium-90 resin microspheres in patients with liver metastases.¹ The studies were designed for a prospective, combined analysis of overall survival, but also reported secondary endpoints including radiological response and liver-specific progression-free survival.

中文翻译：

---

足够的 SIRT 活性剂量与足够的化疗剂量一样重要——作者的回复

FOXFIRE、SIRFLOX 和 FOXFIRE-Global 研究调查了转移性结直肠癌一线化疗与使用钇 90 树脂微球的选择性内放疗 (SIRT) 联合治疗肝转移患者的疗效。¹这些研究旨在对总生存期进行前瞻性综合分析，但也报告了次要终点，包括放射学反应和肝脏特异性无进展生存期。