An organocatalyzed enantioselective Michael–Michael–Michael–aldol cascade reaction for the construction of cyclopentane fused spirooxindoles was achieved. The domino reaction provided the spirooxindoles with six contiguous stereocenters including a quaternary center in good yields (55–64%) with excellent enantioselectivities (up to >99% ee). Enantioselective Michael–Michael–Michael–aldol condensation–aromatization reactions of an isomeric product were observed.

中文翻译：

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有机催化对映选择性Michael–Michael–Michael–Aldol缩合反应：四级联多不对称合成多取代螺环氧化吲哚中的六个立体中心的控制。

实现了有机催化的对映体选择性迈克尔-迈克尔-迈克尔-奥尔多级联反应，用于构建环戊烷稠合的螺氧并吲哚。多米诺骨牌反应为螺硫醇提供了六个连续的立体中心，包括一个具有良好对映选择性（高达> 99％ee）的高产（55-64％）的四元中心。观察到异构产物的对映选择性迈克尔-迈克尔-迈克尔-醛醇缩合-芳香化反应。