Base-Promoted Synthesis of Quinoline-4(1H)-thiones from o-Alkynylanilines and Aroyl Isothiocyanates,Organic Letters

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Base-Promoted Synthesis of Quinoline-4(1H)-thiones from o-Alkynylanilines and Aroyl Isothiocyanates
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acs.orglett.7b02993
Anju Modi ₁ , Prasenjit Sau ₁ , Bhisma K. Patel ₁

Affiliation

A base-promoted synthesis of quinoline-4(1H)-thiones has been accomplished from the in situ generated o-alkynylthiourea, obtained by reacting o-alkynylanilines with aroyl/acyl isothiocyanates. A 6-exo-digS-cyclization of the in situ generated thiourea is followed by a rearrangement to give quinoline-4(1H)-thiones.

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