D-dimer is a soluble fibrin degradation product that results from ordered breakdown of thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis. Consequently, D-dimer has been extensively investigated for the diagnosis of venous thromboembolism (VTE) and is used routinely for this indication. In addition, D-dimer has been evaluated for determining the optimal duration of anticoagulation in VTE patients, for diagnosing and monitoring disseminated intravascular coagulation, and as an aid in the identification of medical patients at high risk for VTE. Thus, quantification of D-dimer levels serves an important role in guiding therapy. This review: 1) describes how D-dimer is generated; 2) reviews the assays used for its detection; and 3) discusses the role of D-dimer determination in these various conditions.

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上下文测试：D-二聚体

D-二聚体是一种可溶性纤维蛋白降解产物，由纤维蛋白溶解系统有序分解血栓形成。大量研究表明，D-二聚体可作为凝血和纤溶激活的重要标志物。因此，D-二聚体已被广泛研究用于诊断静脉血栓栓塞 (VTE) 并常规用于该适应症。此外，D-二聚体已被评估用于确定 VTE 患者抗凝的最佳持续时间，用于诊断和监测弥散性血管内凝血，并有助于识别具有 VTE 高风险的内科患者。因此，D-二聚体水平的量化在指导治疗中起着重要作用。这篇综述：1) 描述了 D-二聚体是如何产生的；2) 审查用于其检测的检测方法；