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TiO2–x Based Nanoplatform for Bimodal Cancer Imaging and NIR-Triggered Chem/Photodynamic/Photothermal Combination Therapy
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1021/acs.chemmater.7b03241 Wei Guo 1 , Fei Wang 1 , Dandan Ding 1 , Chuanqi Song 1 , Chongshen Guo 1 , Shaoqin Liu 1
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1021/acs.chemmater.7b03241 Wei Guo 1 , Fei Wang 1 , Dandan Ding 1 , Chuanqi Song 1 , Chongshen Guo 1 , Shaoqin Liu 1
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Integration of cancer diagnosis and treatment, namely theranostics, is an important issue in the biomedical field. Benefiting from an excellent photothermal effect, ROS generation ability, and the desired mesoporous structure of the TiO2–x matrix, we strategically designed and fabricated a TiO2–x based theranostic system for realizing fluorescence/photoacoustic tomography (PAT) bimodal imaging guided triple therapy for photothemal/photodynamic/chemotherapy in this work. Nonstoichiometric TiO2–x nanospheres are excellent near-infrared absorptive material, which takes on both photosensitizer and photothermal agent roles in implementing PDT/PTT combination therapy and PAT imaging. Moreover, the mesoporous structure of TiO2–x also allowed drug loading, and the polydopamine sealing layer enabled it to induce NIR/pH-triggered drug controlled release. Resultantly, both the in vitro and in vivo experiment manifested the remarkable tumor inhibition and tumor imaging effects by the TiO2–x based theranostic system. The antitumor mechanism was attributable to a synergistic therapeutic effect (combination index = 0.318) of DOX-induced DNA damage, and PDT/PTT caused mitochondrial dysfunction and a change in the cell membrane permeability. Innovatively, the B-mode ultrasonography was adopted to monitor the rehabilitation process at the solid tumor site after treatment, which observed a liquefaction necrosis process.
中文翻译：
基于TiO 2– x的纳米平台用于双峰癌症成像和近红外触发的化学/光动力/光热联合疗法
癌症诊断和治疗（即诊断学）的整合是生物医学领域中的重要问题。得益于出色的光热效应，ROS生成能力以及所需的TiO 2– x基质介孔结构，我们战略性地设计和制造了基于TiO 2– x的诊断体系，以实现荧光/光声层析成像（PAT）双峰成像引导的三重在这项工作中进行光热疗法/光动力疗法/化学疗法的治疗。非化学计量的TiO 2– x纳米球是出色的近红外吸收材料，在实施PDT / PTT组合疗法和PAT成像时，它既具有光敏剂又具有光热剂的作用。此外，TiO的介孔结构2- x也允许药物装载，并且聚多巴胺密封层使其能够诱导NIR / pH触发的药物控制释放。结果，无论是体内还是体外实验都表明，基于TiO 2– x的治疗方法对肿瘤具有显着的抑瘤和显像作用。抗肿瘤机制归因于DOX诱导的DNA损伤的协同治疗作用（组合指数= 0.318），PDT / PTT引起线粒体功能障碍和细胞膜通透性改变。创新地采用B型超声检查来监测治疗后实体瘤部位的康复过程，观察到液化坏死过程。
更新日期：2017-10-31
中文翻译：
基于TiO 2– x的纳米平台用于双峰癌症成像和近红外触发的化学/光动力/光热联合疗法
癌症诊断和治疗（即诊断学）的整合是生物医学领域中的重要问题。得益于出色的光热效应，ROS生成能力以及所需的TiO 2– x基质介孔结构，我们战略性地设计和制造了基于TiO 2– x的诊断体系，以实现荧光/光声层析成像（PAT）双峰成像引导的三重在这项工作中进行光热疗法/光动力疗法/化学疗法的治疗。非化学计量的TiO 2– x纳米球是出色的近红外吸收材料，在实施PDT / PTT组合疗法和PAT成像时，它既具有光敏剂又具有光热剂的作用。此外，TiO的介孔结构2- x也允许药物装载，并且聚多巴胺密封层使其能够诱导NIR / pH触发的药物控制释放。结果，无论是体内还是体外实验都表明，基于TiO 2– x的治疗方法对肿瘤具有显着的抑瘤和显像作用。抗肿瘤机制归因于DOX诱导的DNA损伤的协同治疗作用（组合指数= 0.318），PDT / PTT引起线粒体功能障碍和细胞膜通透性改变。创新地采用B型超声检查来监测治疗后实体瘤部位的康复过程，观察到液化坏死过程。
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