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Benzisoxazole: a privileged scaffold for medicinal chemistry
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7md00449d K P Rakesh 1 , C S Shantharam 2 , M B Sridhara 3 , H M Manukumar 4 , Hua-Li Qin 1
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7md00449d K P Rakesh 1 , C S Shantharam 2 , M B Sridhara 3 , H M Manukumar 4 , Hua-Li Qin 1
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The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.
中文翻译：
苯并异恶唑：药物化学的特殊支架
苯并异恶唑类似物代表了药物化学中的特殊结构之一，并且对含苯并异恶唑化合物的研究越来越多。独特的苯并异恶唑支架还显示出作为抗菌、抗癌、抗炎、抗糖化剂等方面的巨大潜力。这篇综述考察了药物化学的最新技术，因为它涉及不同苯并异恶唑类似物的全面和一般总结，以及它们作为足以推动人类药物试验规模的多种结构的起始构建块的用途。描述含苯并异恶唑的高活性化合物的报道数量令人期待该支架将进一步成为药物发现领域的潜在候选者。
更新日期：2017-10-31
中文翻译：
苯并异恶唑：药物化学的特殊支架
苯并异恶唑类似物代表了药物化学中的特殊结构之一，并且对含苯并异恶唑化合物的研究越来越多。独特的苯并异恶唑支架还显示出作为抗菌、抗癌、抗炎、抗糖化剂等方面的巨大潜力。这篇综述考察了药物化学的最新技术，因为它涉及不同苯并异恶唑类似物的全面和一般总结，以及它们作为足以推动人类药物试验规模的多种结构的起始构建块的用途。描述含苯并异恶唑的高活性化合物的报道数量令人期待该支架将进一步成为药物发现领域的潜在候选者。
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