Four new and five known sesquiterpenoids were isolated from the agarwood of Aquilaria malaccensis. Aquilanols A and B (1 and 2) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound 2 was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.

中文翻译：

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马来沉香沉香中的大环腐草型倍半萜类的Aquilanols A和B。

从马尾沉香的沉香中分离出四种新的和五种已知的倍半萜。天quil醇A和B（1和2）具有空前的大环腐莫林结构，具有双环7/10环系统。得到的化合物2为一种规模的混合物，使用手性柱通过HPLC分析将其拆分。基于光谱数据分析推导了它们的结构，并且通过X射线晶体学数据和ECD光谱分析明确地确定了它们的绝对构型。提出了这些倍半萜的推定生物合成途径。