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Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma
Materials Horizons ( IF 12.2 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1039/c7mh00342k Menghuan Li 1, 2, 3, 4 , Zhong Luo 1, 2, 3, 4, 5 , Zhining Xia 2, 4, 6, 7 , Xinkun Shen 2, 3, 4, 5, 8 , Kaiyong Cai 2, 3, 4, 5, 8
Materials Horizons ( IF 12.2 ) Pub Date : 2017-08-07 00:00:00 , DOI: 10.1039/c7mh00342k Menghuan Li 1, 2, 3, 4 , Zhong Luo 1, 2, 3, 4, 5 , Zhining Xia 2, 4, 6, 7 , Xinkun Shen 2, 3, 4, 5, 8 , Kaiyong Cai 2, 3, 4, 5, 8
Affiliation
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Glioma is the most common malignant brain tumor which has an overall terrible prognosis. Nevertheless, despite the tremendous research input that has been applied to treat gliomas, the efficacy of existing therapeutic modalities on real-life patients is still far from satisfactory, mostly due to several difficult obstacles unique to the CNS and gliomas themselves. Notably, the treatment efficiency of many anti-glioma chemotherapies based on small-molecule anticancer drugs is severely impaired by the blood–brain-barrier, blood–brain–tumor-barrier and resistance mechanisms related to intracranial gliomas, which prevent the therapeutic agents from gaining access to the desired site of action while aggravating associated side effects. Rationally based on the synergistic combination of multiple glioma-specific dosing approaches in chronological order, the time-sequenced targeting strategy is an emerging therapeutic paradigm to address these critical issues, which is capable of efficiently destroying the malignant glioma cells while sparing healthy brain cells and tissues. In this review, we will start with a brief introduction of the major difficulties associated with malignant gliomas and corresponding drug delivery strategies under clinical or laboratory studies, and then comprehensively summarize the recent advances in time-sequenced targeted anti-glioma nanoplatforms, in which their potential benefits and unsolved issues will both be covered.
中文翻译：
按时间顺序给药的方法可有效治疗神经胶质瘤
胶质瘤是最常见的恶性脑肿瘤，其总体预后很差。尽管如此，尽管已将大量的研究投入用于治疗神经胶质瘤，但是现有治疗方式对现实生活中患者的疗效仍远远不能令人满意，这主要是由于中枢神经系统和神经胶质瘤自身所特有的一些困难障碍。值得注意的是，许多基于小分子抗癌药的抗神经胶质瘤化学疗法的治疗效率受到与颅内神经胶质瘤相关的血脑屏障，血脑肿瘤肿瘤屏障和耐药机制的严重损害，从而阻止了治疗药物的产生。在加重相关副作用的同时获得所需的作用部位。合理地基于按时间顺序排列的多种神经胶质瘤特定给药方法的协同组合，按时间顺序的靶向策略是解决这些关键问题的新兴治疗范例，它能够有效破坏恶性神经胶质瘤细胞，同时保留健康的脑细胞和组织。在这篇综述中，我们将简要介绍在临床或实验室研究中与恶性神经胶质瘤相关的主要困难以及相应的药物输送策略，然后全面总结按时间顺序排列的靶向抗神经胶质瘤纳米平台的最新进展，其中潜在的利益和未解决的问题都将包括在内。
更新日期：2017-10-30
中文翻译：
按时间顺序给药的方法可有效治疗神经胶质瘤
胶质瘤是最常见的恶性脑肿瘤，其总体预后很差。尽管如此，尽管已将大量的研究投入用于治疗神经胶质瘤，但是现有治疗方式对现实生活中患者的疗效仍远远不能令人满意，这主要是由于中枢神经系统和神经胶质瘤自身所特有的一些困难障碍。值得注意的是，许多基于小分子抗癌药的抗神经胶质瘤化学疗法的治疗效率受到与颅内神经胶质瘤相关的血脑屏障，血脑肿瘤肿瘤屏障和耐药机制的严重损害，从而阻止了治疗药物的产生。在加重相关副作用的同时获得所需的作用部位。合理地基于按时间顺序排列的多种神经胶质瘤特定给药方法的协同组合，按时间顺序的靶向策略是解决这些关键问题的新兴治疗范例，它能够有效破坏恶性神经胶质瘤细胞，同时保留健康的脑细胞和组织。在这篇综述中，我们将简要介绍在临床或实验室研究中与恶性神经胶质瘤相关的主要困难以及相应的药物输送策略，然后全面总结按时间顺序排列的靶向抗神经胶质瘤纳米平台的最新进展，其中潜在的利益和未解决的问题都将包括在内。
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