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Telomeric TERB1–TRF1 interaction is crucial for male meiosis
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2017-10-30 , DOI: 10.1038/nsmb.3496
Juanjuan Long , Chenhui Huang , Yanyan Chen , Ying Zhang , Shaohua Shi , Ligang Wu , Yie Liu , Chengyu Liu , Jian Wu , Ming Lei

Telomeric TERB1–TRF1 interaction is crucial for male meiosis

Nature Structural & Molecular Biology, Published online: 30 October 2017; doi:10.1038/nsmb.3496

Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading to spermatocyte apoptosis and male infertility in mice.



中文翻译:

端粒TERB1-TRF1相互作用对男性减数分裂至关重要

端粒TERB1-TRF1相互作用对男性减数分裂至关重要

《自然结构与分子生物学》,在线发布:2017年10月30日;doi:10.1038 / nsmb.3496

破坏端粒蛋白TRF1与减数分裂特异性蛋白TERB1之间的相互作用,会破坏它们在粗线粒体中端粒附近的假常染色体区域,从而使X和Y染色体配对受损,从而导致小鼠精细胞凋亡和雄性不育。

更新日期:2017-10-30
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