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Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-10-26 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00554 Sudarat Kruakaew 1 , Chonticha Seeka 1 , Thitima Lhinhatrakool 2 , Sanit Thongnest 3 , Jantana Yahuafai 4 , Suratsawadee Piyaviriyakul 4 , Pongpun Siripong 4 , Somyote Sutthivaiyakit 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-10-26 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00554 Sudarat Kruakaew 1 , Chonticha Seeka 1 , Thitima Lhinhatrakool 2 , Sanit Thongnest 3 , Jantana Yahuafai 4 , Suratsawadee Piyaviriyakul 4 , Pongpun Siripong 4 , Somyote Sutthivaiyakit 1
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Thirteen cardenolide glycosides (1–13) were isolated from the CH2Cl2 and MeOH extracts of Vallaris glabra leaves. The structures of the new compounds (2–13) were identified by spectroscopic methods, with the absolute configurations of the sugar moieties determined by acid hydrolysis. All compounds were evaluated for their cytotoxic activity against human cervix adenocarcinoma, lung carcinoma, and colorectal adenocarcinoma cell lines. The two most potent compounds [2′-O-acetylacoschimperoside P (1) and oleandrigenin-3-O-α-l-2′-O-acetylvallaropyranoside (2)] exhibited IC50 values in the range of 0.03–0.07 μM.
中文翻译：
缬草叶片的细胞毒性心脏糖苷成分
从巴拉瑞斯叶的CH 2 Cl 2和MeOH提取物中分离出13种烯醇内酯苷（1 – 13）。新化合物（的结构2 - 13通过光谱学方法进行了鉴定，与通过酸水解所确定的糖部分的绝对构型）。评价所有化合物对人宫颈腺癌，肺癌和结肠直肠腺癌细胞系的细胞毒活性。两种最有效的化合物[2'- O-乙酰基神经鞘苷P（1）和oleandrigenin-3- O -α- l - 2'- O-乙酰基缬草吡喃糖苷（2）]的IC 50值为0.03-0.07μM。
更新日期：2017-10-26
中文翻译：
缬草叶片的细胞毒性心脏糖苷成分
从巴拉瑞斯叶的CH 2 Cl 2和MeOH提取物中分离出13种烯醇内酯苷（1 – 13）。新化合物（的结构2 - 13通过光谱学方法进行了鉴定，与通过酸水解所确定的糖部分的绝对构型）。评价所有化合物对人宫颈腺癌，肺癌和结肠直肠腺癌细胞系的细胞毒活性。两种最有效的化合物[2'- O-乙酰基神经鞘苷P（1）和oleandrigenin-3- O -α- l - 2'- O-乙酰基缬草吡喃糖苷（2）]的IC 50值为0.03-0.07μM。
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