In response to our manuscript on first-line chemotherapy treatment for metastatic pulmonary large cell neuroendocrine carcinoma (LCNEC) [1], Rossi and co-workers raised their concerns about the validity of our results by questioning the accuracy of LCNEC diagnosis on a biopsy specimen. We would like to thank the authors for their critical appraisal, underscoring the need to increase awareness among pulmonologists, oncologists and pathologists of the diagnostic issues and consequences of metastatic LCNEC diagnosed on a biopsy specimen. Current criteria for LCNEC diagnosed on a biopsy specimen are in need of improvement http://ow.ly/lRP730fu552

中文翻译：

---

为什么我们应该改进目前诊断和治疗晚期患者肺大细胞神经内分泌癌的实践

针对我们关于转移性肺大细胞神经内分泌癌 (LCNEC) 一线化疗的手稿 [1]，Rossi 及其同事通过质疑 LCNEC 对活检标本诊断的准确性提出了他们对我们结果有效性的担忧. 我们要感谢作者的批判性评价，强调需要提高肺病学家、肿瘤学家和病理学家对活检标本诊断出的转移性 LCNEC 的诊断问题和后果的认识。目前通过活检标本诊断 LCNEC 的标准需要改进 http://ow.ly/lRP730fu552