Portable Nitric Oxide (NO) Generator Based on Electrochemical Reduction of Nitrite for Potential Applications in Inhaled NO Therapy and Cardiopulmonary Bypass Surgery,Molecular Pharmaceutics

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Portable Nitric Oxide (NO) Generator Based on Electrochemical Reduction of Nitrite for Potential Applications in Inhaled NO Therapy and Cardiopulmonary Bypass Surgery
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2017-10-25 00:00:00 , DOI: 10.1021/acs.molpharmaceut.7b00514
Yu Qin ₁ , Joanna Zajda ₁ , Elizabeth J. Brisbois ₁ , Hang Ren ₁ , John M. Toomasian ₁ , Terry C. Major ₁ , Alvaro Rojas-Pena ₁ , Benjamin Carr ₁ , Thomas Johnson ₁ , Jonathan W. Haft ₁ , Robert H. Bartlett ₁ , Andrew P. Hunt ₁ , Nicolai Lehnert ₁ , Mark E. Meyerhoff ₁

Affiliation

A new portable gas phase nitric oxide (NO) generator is described for potential applications in inhaled NO (INO) therapy and during cardiopulmonary bypass (CPB) surgery. In this system, NO is produced at the surface of a large-area mesh working electrode by electrochemical reduction of nitrite ions in the presence of a soluble copper(II)-ligand electron transfer mediator complex. The NO generated is then transported into gas phase by either direct purging with nitrogen/air or via circulating the electrolyte/nitrite solution through a gas extraction silicone fiber-based membrane-dialyzer assembly. Gas phase NO concentrations can be tuned in the range of 5–1000 ppm (parts per million by volume for gaseous species), in proportion to a constant cathodic current applied between the working and counter electrodes. This new NO generation process has the advantages of rapid production times (5 min to steady-state), high Faraday NO production efficiency (ca. 93%), excellent stability, and very low cost when using air as the carrier gas for NO (in the membrane dialyzer configuration), enabling the development of potentially portable INO devices. In this initial work, the new system is examined for the effectiveness of gaseous NO to reduce the systemic inflammatory response (SIR) during CPB, where 500 ppm of NO added to the sweep gas of the oxygenator or to the cardiotomy suction air in a CPB system is shown to prevent activation of white blood cells (granulocytes and monocytes) during extracorporeal circulation with cardiotomy suction conducted with five pigs.

中文翻译：

基于亚硝酸盐电化学还原的便携式一氧化氮（NO）发生器，在吸入式NO治疗和心肺旁路手术中的潜在应用

新型便携式气相一氧化氮（NO）发生器被描述为在吸入NO（INO）治疗和体外循环（CPB）手术中的潜在应用。在该系统中，在可溶性铜（II）-配体电子传递介体复合物的存在下，通过亚硝酸根离子的电化学还原，在大面积网状工作电极的表面产生NO。然后，通过用氮气/空气直接吹扫或通过使电解质/亚硝酸盐溶液循环通过基于抽气硅酮纤维的膜透析器组件而将生成的NO输送到气相中。可以根据在工作电极和对电极之间施加恒定的阴极电流的比例，将气相NO的浓度调节在5–1000 ppm（气态物质的百万分之几）的范围内。这种新的NO生成工艺具有以下优势：生产时间短（至稳态需要5分钟），法拉第NO生产效率高（约93％），出色的稳定性以及使用空气作为NO的载气时成本非常低（膜透析器配置中），从而可以开发潜在的便携式INO设备。在这项最初的工作中，将检查新系统在减少CPB期间气态NO减少全身炎症反应（SIR）的有效性，其中将500 ppm NO添加到充氧器的吹扫气或CPB中的心脏切开抽吸空气中该系统被证明可以防止体外循环期间用五头猪进行的心脏切开术吸引白细胞（粒细胞和单核细胞）的活化。93％），出色的稳定性以及使用空气作为NO的载气（在膜透析器配置中）的成本非常低，从而使得潜在的便携式INO设备的开发成为可能。在这项最初的工作中，将检查新系统在减少CPB期间气态NO减少全身炎症反应（SIR）的有效性，其中将500 ppm NO添加到充氧器的吹扫气或CPB中的心脏切开抽吸空气中该系统被证明可以防止体外循环期间用五头猪进行的心脏切开术吸引白细胞（粒细胞和单核细胞）的活化。93％），出色的稳定性以及使用空气作为NO的载气（在膜透析器配置中）的成本非常低，从而使得潜在的便携式INO设备的开发成为可能。在这项最初的工作中，将检查新系统在减少CPB期间气态NO减少全身炎症反应（SIR）的有效性，其中将500 ppm NO添加到充氧器的吹扫气或CPB中的心脏切开抽吸空气中该系统被证明可以防止体外循环期间用五头猪进行的心脏切开术吸引白细胞（粒细胞和单核细胞）的活化。

更新日期：2017-10-26

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