Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2017-10-25 , DOI: 10.1016/j.addr.2017.10.011 Caroline L Wilson 1 , Derek A Mann 1 , Lee A Borthwick 1
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Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/cirrhosis and cancer. Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking. The aim of this review is to present recent findings from the field of liver epigenetics and to explore their potential for translation into therapeutics to prevent disease promoting epigenome reprogramming and reverse epigenetic changes.
中文翻译：
肝纤维化和癌症中的表观遗传重编程
现在正在出现对慢性肝病表观遗传控制的新见解。我们对 DNA 甲基化、组蛋白修饰和 ncRNA 的关键作用的理解的最新进展现在可用于改善对纤维化/肝硬化和癌症的管理。此外，从患者血液和组织中检测表观遗传标记的改进技术将极大地改善诊断、治疗选择和预后跟踪。这篇综述的目的是介绍肝脏表观遗传学领域的最新发现，并探索它们转化为治疗学的潜力，以防止疾病促进表观基因组重编程和逆转表观遗传变化。
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