Follicular thyroid cancer is the second most common differentiated thyroid cancer histological type and has been overshadowed by its more common counterpart-papillary thyroid cancer-despite its unique biological behaviour and less favourable outcomes. In this Review, we comprehensively review the literature on follicular thyroid cancer to provide an evidence-based guide to the management of these tumours, to highlight the lack of evidence behind guideline recommendations, and to identify changes and challenges over the past decades in diagnosis, prognosis, and treatment. We highlight that correct identification of cancer in indeterminate cytological samples is challenging and ultrasonographic features can be misleading. Despite certain unique aspects of follicular thyroid cancer presentation and prognosis, no specific recommendations exist for follicular thyroid cancer and Hürthle cell carcinoma in evidence-based guidelines. Efforts should be made to stimulate additional research in this field.

中文翻译：

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滤泡性甲状腺癌和Hürthle细胞癌：诊断，治疗和临床管理方面的挑战。

滤泡性甲状腺癌是第二种最常见的分化型甲状腺癌组织学类型，尽管其独特的生物学行为和不良的预后，却被其更常见的对应乳头状甲状腺癌所掩盖。在本综述中，我们全面回顾了滤泡性甲状腺癌的文献，为这些肿瘤的治疗提供了循证指南，强调了指南建议背后缺乏证据，并确定了过去几十年的诊断变化和挑战，预后和治疗。我们强调指出，不确定的细胞学样本中正确识别癌症具有挑战性，超声检查特征可能会产生误导。尽管滤泡状甲状腺癌的表现和预后有某些独特的方面，在循证指南中，没有针对滤泡性甲状腺癌和Hürthle细胞癌的具体建议。应努力激发该领域的更多研究。