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PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-23 , DOI: 10.1038/ncb3630 Fabao Liu , Fengfei Ma , Yuyuan Wang , Ling Hao , Hao Zeng , Chenxi Jia , Yidan Wang , Peng Liu , Irene M. Ong , Baobin Li , Guojun Chen , Jiaoyang Jiang , Shaoqin Gong , Lingjun Li , Wei Xu
Nature Cell Biology ( IF 17.3 ) Pub Date : 2017-10-23 , DOI: 10.1038/ncb3630 Fabao Liu , Fengfei Ma , Yuyuan Wang , Ling Hao , Hao Zeng , Chenxi Jia , Yidan Wang , Peng Liu , Irene M. Ong , Baobin Li , Guojun Chen , Jiaoyang Jiang , Shaoqin Gong , Lingjun Li , Wei Xu
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
中文翻译:
CARM1引起的PKM2甲基化激活有氧糖酵解以促进肿瘤发生
CARM1引起的PKM2甲基化激活有氧糖酵解以促进肿瘤发生
更新日期:2017-10-25
Nature Cell Biology, Published online: 23 October 2017; doi:10.1038/ncb3630
Liu et al. find that PKM2 methylated by CARM1 inhibits Ca2+ influx from endoplasmic reticulum to mitochondria, thus restraining mitochondrial oxidative phosphorylation while promoting aerobic glycolysis and breast cancer growth.
中文翻译:
CARM1引起的PKM2甲基化激活有氧糖酵解以促进肿瘤发生
CARM1引起的PKM2甲基化激活有氧糖酵解以促进肿瘤发生
《自然细胞生物学》,在线发布:2017年10月23日; doi:10.1038 / ncb3630
刘等。 发现被CARM1甲基化的PKM2抑制了Ca 2+从内质网向线粒体的流入,从而抑制了线粒体的氧化磷酸化,同时促进了有氧糖酵解和乳腺癌的生长。