当前位置: X-MOL 学术Annu. Rev. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Coping with Protein Quality Control Failure
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-111315-125334
Esther Pilla 1 , Kim Schneider 1 , Anne Bertolotti 1
Affiliation  

Cells and organisms have evolved numerous mechanisms to cope with and to adapt to unexpected challenges and harsh conditions. Proteins are essential to perform the vast majority of cellular and organismal functions. To maintain a healthy proteome, cells rely on a network of factors and pathways collectively known as protein quality control (PQC) systems, which not only ensure that newly synthesized proteins reach a functional conformation but also are essential for surveillance, prevention, and rescue of protein defects. The main players of PQC systems are chaperones and protein degradation systems: the ubiquitin-proteasome system and autophagy. Here we provide an integrated overview of the diverse PQC systems in eukaryotic cells in health and diseases, with an emphasis on the key regulatory aspects and their cross talks. We also highlight how PQC regulation may be exploited for potential therapeutic benefit.

中文翻译:


应对蛋白质质量控​​制失败

细胞和有机体已经进化出许多机制来应对和适应意想不到的挑战和恶劣的条件。蛋白质对于执行绝大多数细胞和有机体功能至关重要。为了维持健康的蛋白质组,细胞依赖于统称为蛋白质质量控​​制 (PQC) 系统的因子和途径网络,这不仅确保新合成的蛋白质达到功能性构象,而且对于监测、预防和拯救蛋白质组至关重要。蛋白质缺陷。PQC 系统的主要参与者是分子伴侣和蛋白质降解系统:泛素-蛋白酶体系统和自噬。在这里,我们提供了对健康和疾病中真核细胞中不同 PQC 系统的综合概述,重点是关键监管方面及其交叉对话。

更新日期:2017-10-06
down
wechat
bug