[¹¹C]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [¹¹C]-S-methyl-14-thiomyristic acid (b), [¹¹C]-S-methyl-12-thiododecanoic acid (c) and [¹¹C]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium. Small animal PET images of the accumulation of a in the rat myocardium were clearly superior to [¹¹C]-palmitate. These initial studies suggest that a could be a potentially useful clinical PET tracer to assess myocardial fatty acid metabolism.

[ ¹¹ C] -S-甲基-16-硫代棕榈酸（a）具有优异的心脏与背景摄取比和更高的心脏保留率。示踪剂的心肌摄取和代谢明显取决于CPTI。当与[ ¹¹ C] -S-甲基-14-硫代肉豆蔻酸（b），[ ¹¹ C] -S-甲基-12-硫代十二酸（c）和[ ¹¹ C] -棕榈酸相比时，a表现出较高的早期摄取并显着减慢了心脏的后期清除速度，延长了心肌消除半衰期（30分钟）。心脏组织和尿液样本的分析表明，一在心肌中通过β-氧化代谢。大鼠心肌中a积累的小动物PET图像明显优于[ ¹¹ C]棕榈酸酯。这些初步研究表明，a可能是评估心肌脂肪酸代谢的潜在有用的临床PET示踪剂。