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Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency
Molecular Cell ( IF 14.5 ) Pub Date : 2017-10-19 , DOI: 10.1016/j.molcel.2017.10.005 François Robert
中文翻译:
Spt6阻碍Polycomb促进ESC多能性
更新日期:2017-10-19
Molecular Cell ( IF 14.5 ) Pub Date : 2017-10-19 , DOI: 10.1016/j.molcel.2017.10.005 François Robert
Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.
中文翻译:
Spt6阻碍Polycomb促进ESC多能性
尽管表达高水平的Polycomb组蛋白,但胚胎干细胞(ESC)难以抵抗H3K27三甲基化,尤其是在调节关键多能性基因的超级增强子中。在本期《分子细胞》中,Wang等人。(2017)报告说,组蛋白伴侣Spt6阻止了关键ESC超级增强剂的H3K27三甲基化。