Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.

中文翻译：

---

Spt6阻碍Polycomb促进ESC多能性

尽管表达高水平的Polycomb组蛋白，但胚胎干细胞（ESC）难以抵抗H3K27三甲基化，尤其是在调节关键多能性基因的超级增强子中。在本期《分子细胞》中，Wang等人。（2017）报告说，组蛋白伴侣Spt6阻止了关键ESC超级增强剂的H3K27三甲基化。