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Multivalent Presentation of Cationic Peptides on Supramolecular Nanofibers for Antimicrobial Activity
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2017-10-19 00:00:00 , DOI: 10.1021/acs.molpharmaceut.7b00434 Mustafa Beter 1 , Hatice K. Kara 1 , Ahmet E. Topal 1 , Aykutlu Dana 1 , Ayse B. Tekinay 1, 2 , Mustafa O. Guler 3
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2017-10-19 00:00:00 , DOI: 10.1021/acs.molpharmaceut.7b00434 Mustafa Beter 1 , Hatice K. Kara 1 , Ahmet E. Topal 1 , Aykutlu Dana 1 , Ayse B. Tekinay 1, 2 , Mustafa O. Guler 3
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Noncovalent and electrostatic interactions facilitate the formation of complex networks through molecular self-assembly in biomolecules such as proteins and glycosaminoglycans. Self-assembling peptide amphiphiles (PA) are a group of molecules that can form nanofibrous structures and may contain bioactive epitopes to interact specifically with target molecules. Here, we report the presentation of cationic peptide sequences on supramolecular nanofibers formed by self-assembling peptide amphiphiles for cooperative enhanced antibacterial activity. Antibacterial properties of self-assembled peptide nanofibers were significantly higher than soluble peptide molecules with identical amino acid sequences, suggesting that the tandem presentation of bioactive epitopes is important for designing new materials for bactericidal activity. In addition, bacteria were observed to accumulate more rapidly on peptide nanofibers compared to soluble peptides, which may further enhance antibacterial activity by increasing the number of peptide molecules interacting with the bacterial membrane. The cationic peptide amphiphile nanofibers were observed to attach to bacterial membranes and disrupt their integrity. These results demonstrate that short cationic peptides show a significant improvement in antibacterial activity when presented in the nanofiber form.
中文翻译：
阳离子肽在超分子纳米纤维上的抗菌活性的多价呈递。
非共价和静电相互作用通过生物分子（例如蛋白质和糖胺聚糖）中的分子自组装，促进了复杂网络的形成。自组装肽两亲物（PA）是一组可以形成纳米纤维结构的分子，可能包含生物活性表位以与目标分子发生特异性相互作用。在这里，我们报告了由自组装肽两亲物形成的超分子纳米纤维上阳离子肽序列的协同增强抗菌活性的介绍。自组装肽纳米纤维的抗菌性能显着高于具有相同氨基酸序列的可溶性肽分子，这表明生物活性表位的串联呈递对于设计具有杀菌活性的新材料很重要。此外，与可溶性肽相比，观察到细菌在肽纳米纤维上的积累更快，这可能通过增加与细菌膜相互作用的肽分子的数量来进一步增强抗菌活性。观察到阳离子肽两亲纳米纤维附着在细菌膜上并破坏了它们的完整性。这些结果表明，当以纳米纤维形式存在时，短阳离子肽显示出显着的抗菌活性改善。
更新日期：2017-10-20
中文翻译：
阳离子肽在超分子纳米纤维上的抗菌活性的多价呈递。
非共价和静电相互作用通过生物分子（例如蛋白质和糖胺聚糖）中的分子自组装，促进了复杂网络的形成。自组装肽两亲物（PA）是一组可以形成纳米纤维结构的分子，可能包含生物活性表位以与目标分子发生特异性相互作用。在这里，我们报告了由自组装肽两亲物形成的超分子纳米纤维上阳离子肽序列的协同增强抗菌活性的介绍。自组装肽纳米纤维的抗菌性能显着高于具有相同氨基酸序列的可溶性肽分子，这表明生物活性表位的串联呈递对于设计具有杀菌活性的新材料很重要。此外，与可溶性肽相比，观察到细菌在肽纳米纤维上的积累更快，这可能通过增加与细菌膜相互作用的肽分子的数量来进一步增强抗菌活性。观察到阳离子肽两亲纳米纤维附着在细菌膜上并破坏了它们的完整性。这些结果表明，当以纳米纤维形式存在时，短阳离子肽显示出显着的抗菌活性改善。
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