Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many diseases, the Hippo pathway is also involved in the pathophysiology of diabetes on the level of the pancreatic islets. Multiple lines of evidence uncover the importance of Hippo signaling in pancreas development as well as in the regulation of β-cell survival, proliferation, and regeneration. Hippo therefore represents a potential target for therapeutic agents designed to improve β-cell function and survival in diabetes. In this review, we summarize recent data on the regulation of the Hippo signaling pathway in the pancreas/in pancreatic islets, its functions on β-cell homeostasis in physiology and pathophysiology, and its contribution toward diabetes progression. The current knowledge related to general mechanisms of action and the possibility of exploiting the Hippo pathway for therapeutic approaches to block β-cell failure in diabetes is highlighted.

中文翻译：

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胰腺β细胞中的河马信号通路：功能和调节。

河马信号传导是一种进化保守的途径，可响应广泛的细胞外和细胞内信号，关键性地调节各种组织的发育和体内平衡。作为许多疾病中新兴的重要角色，河马途径还涉及胰岛水平的糖尿病的病理生理学。多种证据揭示了Hippo信号传导在胰腺发育以及调节β细胞存活，增殖和再生中的重要性。因此，河马代表了旨在改善β的治疗剂的潜在靶标细胞功能和糖尿病的存活率。在这篇综述中，我们总结了有关胰腺/胰岛中Hippo信号通路的调控，其对生理和病理生理学中β细胞稳态的功能及其对糖尿病进展的贡献的最新数据。强调了与一般作用机制有关的当前知识以及利用Hippo途径治疗糖尿病β细胞衰竭的治疗方法的可能性。