On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway diseases such as asthma and chronic obstructive pulmonary disease. It is now clear that both are complex and heterogeneous diseases, that often overlap and that both require individualised assessment and treatment. This paper summarises the presentations and discussions that took place during the seminar. Specifically, we discussed the need for a new taxonomy of human diseases, the role of different players in this scenario (exposome, genes, endotypes, phenotypes, biomarkers and treatable traits) and a number of unanswered key questions in the field. We also addressed how to deploy airway precision medicine in clinical practice today, both in primary and specialised care. Finally, we debated the type of research needed to move the field forward. This paper discusses how to implement precision medicine in patients with chronic airway diseases http://ow.ly/R8wc30fgyyv

中文翻译：

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气道疾病的精准医学：转向临床实践

2017 年 2 月 21 日，欧洲呼吸学会研究研讨会在巴塞罗那举行，讨论了如何最好地将精准医学应用于哮喘和慢性阻塞性肺病等慢性气道疾病。现在很清楚，两者都是复杂且异质的疾病，经常重叠，都需要个体化评估和治疗。本文总结了研讨会期间的演讲和讨论。具体来说，我们讨论了对人类疾病新分类的需求、不同参与者在这种情况下的作用（暴露体、基因、内型、表型、生物标志物和可治疗性状）以及该领域的一些未解决的关键问题。我们还讨论了如何在今天的临床实践中部署气道精准医学，包括初级和专科护理。最后，我们讨论了推动该领域向前发展所需的研究类型。本文探讨如何在慢性气道疾病患者中实施精准医疗 http://ow.ly/R8wc30fgyyv