Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast,Journal of Natural Products

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Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-10-18 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00714
Charlotte Leman-Loubière ₁ , Géraldine Le Goff ₁ , Pascal Retailleau ₁ , Cécile Debitus ₂ , Jamal Ouazzani ₁

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Two sporothriolide-related compounds were obtained from an extract of the fungus Hypoxylon monticulosum CLL-205, isolated from a Sphaerocladina sponge collected from the Tahiti coast. Compound 2 is a deoxy analogue of sporothric acid (4). Compound 3 is a newly reported unusual scaffold combining sporothriolide (1) and trienylfuranol A (5) moieties, through a Diels–Alderase-type reaction. Various experimental and analytical arguments supported the biocatalytic origin of compound 3. The structures of the isolated compounds were elucidated using 1D and 2D NMR, HRMS, and IR data. The structure and the absolute configuration of 3 were unambiguously confirmed by a single-crystal X-ray diffraction analysis.

中文翻译：

分离自塔希提岛海岸球菌海绵的真菌Hypoxylon monticulosum CLL-205中与孢霉内酯有关的化合物

从从塔希提岛海岸收集的Sphaerocladina海绵中分离出的真菌Hypoxylon monticulosum CLL-205的提取物中获得了两种与孢丝虫内酯相关的化合物。化合物2是孢子酸（4）的脱氧类似物。化合物3是一种新报道的不寻常的支架，通过Diels-Alderase型反应结合了孢子囊内酯（1）和三烯基呋喃醇A（5）部分。各种实验和分析论据支持了化合物3的生物催化起源。使用1D和2D NMR，HRMS和IR数据阐明了分离出的化合物的结构。的结构和绝对配置通过单晶X射线衍射分析明确地确认了3个。

更新日期：2017-10-18

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