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Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging
Materials & Design ( IF 7.6 ) Pub Date : 2018-01-01 , DOI: 10.1016/j.matdes.2017.10.047
Feng-Lei Zhou 1, 2, 3 , Zhanxiong Li 4 , Julie E Gough 3 , Penny L Hubbard Cristinacce 5 , Geoff J M Parker 1, 2, 6
Affiliation  

Highly hydrophilic hollow polycaprolactone (PCL) microfibres were developed as building elements to create tissue-mimicking test objects (phantoms) for validation of diffusion magnetic resonance imaging (MRI). These microfibres were fabricated by the co-electrospinning of PCL-polysiloxane-based surfactant (PSi) mixture as shell and polyethylene oxide as core. The addition of PSi had a significant effect on the size of resultant electrospun fibres and the formation of hollow microfibres. The presence of PSi in both co-electrospun PCL microfibre surface and cross-section, revealed by X-ray energy dispersive spectroscopy (EDX), enabled water to wet these fibres completely (i.e., zero contact angle) and remained active for up to 12 months after immersing in water. PCL and PCL-PSi fibres with uniaxial orientation were constructed into water-filled phantoms. MR measurement revealed that water molecules diffuse anisotropically in the PCL-PSi phantom. Co-electrospun hollow PCL-PSi microfibres have desirable hydrophilic properties for the construction of a new generation of tissue-mimicking dMRI phantoms.

中文翻译:


用于扩散磁共振成像的轴突模拟亲水空心聚己内酯微纤维



高亲水性中空聚己内酯 (PCL) 微纤维被开发为建筑元件,用于创建模拟组织的测试对象(模型),用于验证扩散磁共振成像 (MRI)。这些微纤维是通过共静电纺丝以 PCL-聚硅氧烷基表面活性剂 (PSi) 混合物为壳、聚环氧乙烷为核而制成的。 PSi 的添加对所得静电纺丝纤维的尺寸和中空微纤维的形成具有显着影响。 X 射线能量色散光谱 (EDX) 显示,共静电纺 PCL 微纤维表面和横截面中存在 PSi,使水能够完全润湿这些纤维(即零接触角),并在长达 12 的时间内保持活性。浸入水中几个月后。将单轴取向的 PCL 和 PCL-PSi 纤维构建成充满水的模型。 MR 测量表明水分子在 PCL-PSi 体模中各向异性扩散。共电纺空心 PCL-PSi 微纤维具有理想的亲水特性,可用于构建新一代模拟组织 dMRI 模型。
更新日期:2018-01-01
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