Glycopolymers Bearing Galactose and Betulin: Synthesis, Encapsulation, and Lectin Recognition,Biomacromolecules

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Glycopolymers Bearing Galactose and Betulin: Synthesis, Encapsulation, and Lectin Recognition
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1021/acs.biomac.7b01106
Zhiyuan Ma ₁ , Yong-Guang Jia ₁ , X. X. Zhu ₁

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Betulin is a natural triterpene compound with anticarcinogen and antiviral activities. It is conjugated with methacrylate and then copolymerized with a galactose-bearing comonomer by RAFT polymerization to yield both random and block copolymers. These glycopolymers are designed to possess similar molecular weights and monomer compositions for easy comparison. They self-assembled into micelles, as shown by dynamic light scattering (DLS) and transmission electron microscopy. The smaller micelles formed by the random copolymers facilitated the encapsulation of Nile Red and released more of this hydrophobic model compound (46% in 4 days versus 32% released from the block copolymers). These glycopolymers interacted with lectins, such as RCA₁₂₀, as studied by turbidity assay and DLS. The block copolymers formed larger aggregates and clustered faster than the random copolymers. The betulin-based glycopolymers may serve as biocompatible multifunctional biomaterials and carriers for use in targeted release of drugs.

中文翻译：

含半乳糖和白蛋白的糖聚合物：合成，封装和凝集素识别。

桦木蛋白是具有抗癌剂和抗病毒活性的天然三萜化合物。它与甲基丙烯酸酯共轭，然后通过RAFT聚合与带有半乳糖的共聚单体共聚，从而生成无规共聚物和嵌段共聚物。这些糖聚合物被设计为具有相似的分子量和单体组成，以便于比较。它们自组装成胶束，如动态光散射（DLS）和透射电子显微镜所示。由无规共聚物形成的较小的胶束促进了尼罗红的包封，并释放了更多的这种疏水性模型化合物（4天为46％，而嵌段共聚物为32％）。这些糖聚合物与凝集素（例如RCA _120）相互作用，通过浊度分析和DLS进行研究。嵌段共聚物比无规共聚物形成更大的聚集体并且聚集更快。基于桦木素的糖聚合物可以用作生物相容性多功能生物材料和载体，用于靶向释放药物。

更新日期：2017-10-17

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