From the cultured endophytic fungus Glomerella cingulata isolated from a toxic plant, Gelsemium elegans, one new phenanthrene (1), four new sesquiterpenes (2–5), and three known sesquiterpenes (6–8) were isolated. Their structures were elucidated using spectroscopic methods. Based on the ECD calculations, the absolute configurations of the new compounds were determined. Compounds 2, 4, and 5 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells by 50.6, 36.1, and 29.4%, respectively, at 1 μM (positive control curcumin, IC₅₀ = 4.0 μM).

中文翻译：

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内生菌克氏菌中的倍半萜

从培养的内生真菌苹果炭疽病菌从植物毒性，分离钩吻，一个新的菲（1），四个新的倍半萜烯（2 - 5），和三种已知的倍半萜烯（6 - 8）中分离得到。使用光谱学方法阐明了它们的结构。根据ECD计算，确定了新化合物的绝对构型。化合物2，4，和5抑制脂多糖（LPS）诱导的NO在细胞BV2生产50.6，36.1，和29.4％，分别在1μM（阳性对照姜黄素，IC ₅₀ = 4.0微米）。