Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.

中文翻译：

---

cGAS微管理遗传毒性胁迫

维持基因组完整性对于预防癌症至关重要。基因毒性应力通过形成微核将受损的DNA驱逐出核。《自然》杂志上的两项研究揭示了胞质DNA传感器cGAS如何进入微核内的货物以驱动I型IFN反应。