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Batch Injection Analysis‐Multiple Pulse Amperometric Fingerprint: A Simple Approach for Fast On‐site Screening of Drugs
Electroanalysis ( IF 2.7 ) Pub Date : 2017-10-17 , DOI: 10.1002/elan.201700520 Camila Garcia Cardozo 1 , Rafael Melo Cardoso 2 , Thiago Matheus Guimarães Selva 3, 4 , Adriana Evaristo de Carvalho 1 , Wallans Torres Pio dos Santos 5 , Thiago Regis Longo Cesar Paixão 3 , Rodrigo Amorim Bezerra da Silva 1, 2
Electroanalysis ( IF 2.7 ) Pub Date : 2017-10-17 , DOI: 10.1002/elan.201700520 Camila Garcia Cardozo 1 , Rafael Melo Cardoso 2 , Thiago Matheus Guimarães Selva 3, 4 , Adriana Evaristo de Carvalho 1 , Wallans Torres Pio dos Santos 5 , Thiago Regis Longo Cesar Paixão 3 , Rodrigo Amorim Bezerra da Silva 1, 2
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In this work, the association of batch injection analysis with multiple pulse amperometric detection (BIA‐MPA) is presented as a new approach to obtain drugs fingerprints. To illustrate the potential of this screening method, tablets containing sildenafil as the active substance were used. Here, a sequence of three potential pulses as a function of time (+1.3, +1.6 and +2.1 V) were applied on a boron‐doped diamond electrode while reproducible injections were performed in a BIA cell (wall jet configuration). The chemical profile of the respective drug combined three ratios among the peak currents obtained in each amperogram: R1=ipa1.6V/ipa1.3V, R2=ipa2.1V/ipa1.6V, R3=ipa2.1V/ipa1.3V. This simple protocol allowed discrimination between Viagra® (reference)/generic and two smuggled tablets, as well as pure Viagra® from Viagra® adulterated with other electroactive compounds (caffeine, dipyrone, paracetamol and tadalafil). For comparison, screening of these samples was also performed using square wave voltammetry combined with a chemometric method (principal component analysis), in which was achieved similar discrimination by one or other strategy for the most of drugs. This new BIA‐MPA fingerprinting combines desirable features in forensic science such as low cost, simplicity, high sample throughput (two drugs discerned in less than 30 s) and portability (screening at the place of the seizure).
中文翻译：
批量注射分析-多脉冲安培指纹图谱：快速现场筛选药物的简单方法
在这项工作中，批处理进样分析与多脉冲安培检测（BIA-MPA）的关联被呈现为一种获取药物指纹图谱的新方法。为了说明这种筛选方法的潜力，使用了含有西地那非作为活性物质的片剂。此处，在硼掺杂的金刚石电极上施加了三个随时间变化的电位脉冲序列（+ 1.3，+ 1.6和+2.1 V），同时在BIA电池（壁喷射配置）中进行了可重现的注入。每种药物的化学图谱结合了在每个安培图中获得的峰值电流中的三个比率：R 1 = ipa 1.6V / ipa 1.3V，R 2 = ipa 2.1V / ipa 1.6V，R 3= ipa 2.1V / ipa 1.3V。这种简单的方案可以区分（参比）/仿制药和两种走私片，以及掺有其他电活性化合物（咖啡因，双嘧达隆，扑热息痛和他达拉非的）的来自Viagra®的纯Viagra®。为了进行比较，还使用方波伏安法结合化学计量学方法（主要成分分析）对这些样品进行了筛选，其中一种或多种其他药物对大多数药物的识别方法相似。这种新的BIA-MPA指纹技术结合了法医学的理想功能，例如成本低，操作简便，样品通量高（在不到30秒的时间内即可分辨出两种药物）和便携性（在癫痫发作部位进行筛查）。
更新日期：2017-10-17
中文翻译：
批量注射分析-多脉冲安培指纹图谱：快速现场筛选药物的简单方法
在这项工作中，批处理进样分析与多脉冲安培检测（BIA-MPA）的关联被呈现为一种获取药物指纹图谱的新方法。为了说明这种筛选方法的潜力，使用了含有西地那非作为活性物质的片剂。此处，在硼掺杂的金刚石电极上施加了三个随时间变化的电位脉冲序列（+ 1.3，+ 1.6和+2.1 V），同时在BIA电池（壁喷射配置）中进行了可重现的注入。每种药物的化学图谱结合了在每个安培图中获得的峰值电流中的三个比率：R 1 = ipa 1.6V / ipa 1.3V，R 2 = ipa 2.1V / ipa 1.6V，R 3= ipa 2.1V / ipa 1.3V。这种简单的方案可以区分（参比）/仿制药和两种走私片，以及掺有其他电活性化合物（咖啡因，双嘧达隆，扑热息痛和他达拉非的）的来自Viagra®的纯Viagra®。为了进行比较，还使用方波伏安法结合化学计量学方法（主要成分分析）对这些样品进行了筛选，其中一种或多种其他药物对大多数药物的识别方法相似。这种新的BIA-MPA指纹技术结合了法医学的理想功能，例如成本低，操作简便，样品通量高（在不到30秒的时间内即可分辨出两种药物）和便携性（在癫痫发作部位进行筛查）。
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