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Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : , DOI: 10.1038/nsmb.3486 Stefano Stella , Pablo Alcón , Guillermo Montoya
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : , DOI: 10.1038/nsmb.3486 Stefano Stella , Pablo Alcón , Guillermo Montoya
Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing
中文翻译:
2级CRISPR–Cas RNA引导的核酸内切酶:瑞士军刀进行基因组编辑
2级CRISPR–Cas RNA引导的核酸内切酶:瑞士军刀进行基因组编辑
更新日期:2017-10-16
Nature Structural & Molecular Biology, Published online: 16 October 2017; doi:10.1038/nsmb.3486
This review highlights recent mechanistic insights into the CRISPR class 2 type V enzymes Cpf1 and C2c1, which are crucial for improving these genome engineering tools and expanding the genomic editing space.
中文翻译:
2级CRISPR–Cas RNA引导的核酸内切酶:瑞士军刀进行基因组编辑
2级CRISPR–Cas RNA引导的核酸内切酶:瑞士军刀进行基因组编辑
《自然结构与分子生物学》,在线发布:2017年10月16日;doi:10.1038 / nsmb.3486
这篇综述着重介绍了对CRISPR 2类V型酶Cpf1和C2c1的近期机理性见解,这对于改善这些基因组工程工具和扩大基因组编辑空间至关重要。