A lossy mode resonance (LMR) based sensor for urinary p-cresol testing on optical fiber substrate is developed. The sensor probe fabrication includes dip coating of nanocomposite layer of zinc oxide and molybdenum sulphide (ZnO/MoS₂) over unclad core of optical fiber as the transducer layer followed by the layer of molecular imprinted polymer (MIP) as the recognition medium. The addition of molybdenum sulphide in the transducer layer increases the absorption of light in the medium which enhances the LMR properties of zinc oxide thereby increasing the conductivity and hence the sensitivity of the sensor. The sensor probe is characterized for p-cresol concentration range from 0 µM (reference sample) to 1000 µM in artificially prepared urine. Optimizations of various probe fabrication parameters are carried to bring out the sensor's optimal performance with a sensitivity of 11.86 nm/µM and 28 nM as the limit of detection (LOD). A two-order improvement in LOD is obtained as compared to the recently reported p-cresol sensor. The proposed sensor possesses a response time of 15 s which is 8 times better than that reported in the literature utilizing electrochemical method. Its response time is also better than the p-cresol sensor currently available in the market for the medical field. Thus, with a fast response, significant stability and repeatability, the proposed sensor holds practical implementation possibilities in the medical field. Further, the realization of sensor probe over optical fiber substrate adds remote sensing and online monitoring feasibilities.

开发了一种基于损耗模式共振（LMR）的传感器，用于在光纤基板上进行尿对甲酚测试。传感器探头的制造包括对氧化锌和硫化钼（ZnO / MoS ₂）在光纤的未包覆芯层上作为换能器层，然后是分子印迹聚合物（MIP）层作为识别介质。在换能器层中添加硫化钼增加了介质中光的吸收，从而增强了氧化锌的LMR特性，从而提高了电导率，从而提高了传感器的灵敏度。传感器探针的特征在于在人工制备的尿液中对甲酚的浓度范围为0 µM（参考样品）至1000 µM。进行了各种探针制造参数的优化，以达到传感器的最佳性能，其灵敏度为11.86 nm / µM，检测极限（LOD）为28 nM。与最近报道的对甲酚传感器相比，LOD得到了两级改善。所提出的传感器具有15 s的响应时间，比使用电化学方法的文献报道的响应时间长8倍。它的响应时间也比目前市场上用于医疗领域的对甲酚传感器要好。因此，以快速的响应，显着的稳定性和可重复性，所提出的传感器在医学领域具有实际的实现可能性。此外，在光纤基板上实现传感器探针增加了遥感和在线监控的可行性。所提出的传感器在医学领域具有实际的实现可能性。此外，在光纤基板上实现传感器探针增加了遥感和在线监控的可行性。所提出的传感器在医学领域具有实际的实现可能性。此外，在光纤基板上实现传感器探针增加了遥感和在线监控的可行性。