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Preserving protein function through reversible aggregation
Nature Cell Biology ( IF 17.3 ) Pub Date : , DOI: 10.1038/ncb3620 Jörg Höhfeld
Nature Cell Biology ( IF 17.3 ) Pub Date : , DOI: 10.1038/ncb3620 Jörg Höhfeld
Preserving protein function through reversible aggregation
中文翻译:
通过可逆聚集保持蛋白质功能
通过可逆聚集保持蛋白质功能
更新日期:2017-10-12
Nature Cell Biology, Published online: 29 September 2017; doi:10.1038/ncb3620
It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress.
中文翻译:
通过可逆聚集保持蛋白质功能
通过可逆聚集保持蛋白质功能
《自然细胞生物学》(Nature Cell Biology),在线发布:2017年9月29日;doi:10.1038 / ncb3620
人们普遍认为蛋白质功能取决于定义的3D结构,其展开和聚集会对功能造成最后的打击。现在的一项研究表明,酵母丙酮酸激酶中非结构化区域的受调控暴露会触发可逆聚集,从而在压力下保持蛋白质功能。