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What DKKtates where to metastasize
Nature Cell Biology ( IF 21.3 ) Pub Date :  , DOI: 10.1038/ncb3621
Wei Zheng , Jeffrey W. Pollard

What DKKtates where to metastasize

Nature Cell Biology, Published online: 29 September 2017; doi:10.1038/ncb3621

Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.



中文翻译:

什么DKKtates转移到哪里

什么DKKtates转移到哪里

《自然细胞生物学》(Nature Cell Biology),在线发布:2017年9月29日;doi:10.1038 / ncb3621

癌细胞优先转移到某些器官。在乳腺癌小鼠模型中的一项研究表明,由于两种微环境中经典和非经典WNT信号的差异调节,WNT信号的DKK1负调节剂抑制了向肺的向性,但增强了对骨骼的向性。

更新日期:2017-10-12
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