Gut microbes impact host metabolism via a multitude of mechanisms, including through host circadian rhythm regulation. How microbes influence host circadian networks remains unclear. Recently, Wang et al. (2017) showed that crosstalk between specific microbial components and innate immune cells tunes epithelial circadian oscillations via Nfil3, modulating lipid uptake and metabolism.

中文翻译：

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为接力比赛争取时间

肠道微生物通过多种机制影响宿主代谢，包括通过宿主昼夜节律调节。微生物如何影响宿主昼夜节律网络尚不清楚。最近，Wang等。（2017）显示特定微生物成分与先天免疫细胞之间的串扰通过Nfil3调节上皮昼夜节律振荡，调节脂质摄取和代谢。