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Development of a Sensor Based on Modified Carbon Paste with Com Iron(III) Protoporphyrin Immobilized on SiNbZn Silica Matrix for L‐tryptophan Determination
Electroanalysis ( IF 2.7 ) Pub Date : 2017-10-12 , DOI: 10.1002/elan.201700476 Daniela Nunes da Silva 1 , César Ricardo Teixeira Tarley 2 , Arnaldo César Pereira 1
Electroanalysis ( IF 2.7 ) Pub Date : 2017-10-12 , DOI: 10.1002/elan.201700476 Daniela Nunes da Silva 1 , César Ricardo Teixeira Tarley 2 , Arnaldo César Pereira 1
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In this work, SiO2/Nb2O5/ZnO prepared by the sol‐gel processing method was used as substrate base for immobilization of the protoporphyrin‐IX ion. Iron(III) ion was inserted into the porphyrin ring (SiNbZn‐PPFe). A simple square wave voltammetry method based on a composite sensor carbon paste electrode of this material,designed as EPC‐SiNbZn‐PPFe, was developed and validated successfully for the determination of L‐tryptophan (Trp). The optimum conditions were obtained by using sensor modified with 18.00 mg SiNbZn‐PPFe material, 12.00 mg graphite powder and 6.0 μL mineral oil and phosphate buffer 0.3 mol L−1 pH 7.0. The sensitivity of the sensor was found to be 0.523 AL mol −1, linear range from 10 to 70 μmol L−1 and limit of detection of 3.28 μmol L−1. Therefore, the developed method was successfully applied for the Trp determination in real samples of pharmaceutical formulation and can be used for routine quality control pharmaceutical formulations containing Trp.
中文翻译：
基于修饰的碳糊的固定化SiNbZn二氧化硅基质上的ComN铁原卟啉修饰碳糊测定L色氨酸的传感器的开发
在这项工作中，通过溶胶-凝胶法制备的SiO 2 / Nb 2 O 5 / ZnO被用作固定原卟啉-IX离子的基质。铁（III）离子被插入到卟啉环（SiNbZn-PPFe）中。开发了一种基于这种材料的复合传感器碳糊电极的简单方波伏安法，设计为EPC-SiNbZn-PPFe，并成功验证了L-色氨酸（Trp）的测定。最佳条件是通过使用经18.00 mg SiNbZn-PPFe材料，12.00 mg石墨粉和6.0μL矿物油以及0.3 mol L -1 pH 7.0的磷酸盐缓冲液改性的传感器获得的。发现传感器的灵敏度为0.523 AL mol -1，线性范围为10至70μmolL -1，检出限为3.28μmolL -1。因此，所开发的方法已成功地用于药物制剂实际样品中的Trp测定，并可用于包含Trp的常规质量控制药物制剂。
更新日期：2017-10-12
中文翻译：
基于修饰的碳糊的固定化SiNbZn二氧化硅基质上的ComN铁原卟啉修饰碳糊测定L色氨酸的传感器的开发
在这项工作中，通过溶胶-凝胶法制备的SiO 2 / Nb 2 O 5 / ZnO被用作固定原卟啉-IX离子的基质。铁（III）离子被插入到卟啉环（SiNbZn-PPFe）中。开发了一种基于这种材料的复合传感器碳糊电极的简单方波伏安法，设计为EPC-SiNbZn-PPFe，并成功验证了L-色氨酸（Trp）的测定。最佳条件是通过使用经18.00 mg SiNbZn-PPFe材料，12.00 mg石墨粉和6.0μL矿物油以及0.3 mol L -1 pH 7.0的磷酸盐缓冲液改性的传感器获得的。发现传感器的灵敏度为0.523 AL mol -1，线性范围为10至70μmolL -1，检出限为3.28μmolL -1。因此，所开发的方法已成功地用于药物制剂实际样品中的Trp测定，并可用于包含Trp的常规质量控制药物制剂。
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