Paediatric endocrinology: Can niacin supplementation protect against congenital malformations?

Nature Reviews Endocrinology, Published online: 11 October 2017; doi:10.1038/nrendo.2017.133

A recent report found mutations in the de novo kynurenine pathway and reduced plasma levels of NAD in patients with congenital malformations. In a mouse model, the mutation not only altered the phenotype of the litters but the combination of a homozygous mutation and a niacin-free diet resulted in miscarriages.

中文翻译：

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儿科内分泌学：补充烟酸可以预防先天性畸形吗？

儿科内分泌学：补充烟酸可以预防先天性畸形吗？

Nature Reviews Endocrinology，在线发表：2017 年 10 月 11 日；doi:10.1038/nrendo.2017.133

最近的一份报告发现先天性畸形患者的新生犬尿氨酸通路发生突变，血浆 NAD+ 水平降低。在小鼠模型中，突变不仅改变了幼崽的表型，而且纯合突变和无烟酸饮食的结合导致了流产。