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Fine-tuning PERK signaling to control cell fate under stress
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date :  , DOI: 10.1038/nsmb.3478
Hery Urra , Claudio Hetz

Fine-tuning PERK signaling to control cell fate under stress

Nature Structural & Molecular Biology, Published online: 5 October 2017; doi:10.1038/nsmb.3478

PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK–CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.



中文翻译:

微调PERK信号以控制压力下的细胞命运

微调PERK信号以控制压力下的细胞命运

《自然结构与分子生物学》,在线发布:2017年10月5日;doi:10.1038 / nsmb.3478

PERK是内质网(ER)胁迫下未折叠的蛋白反应控制细胞命运的主要传感器。一项新研究揭示了最佳PERK信号传导的另一步骤,涉及CNPY2与PERK的管腔结构域的结合。研究表明,PERK–CNPY2轴可在内质网应激下增加细胞死亡,从而影响肝脏疾病。

更新日期:2017-10-11
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