Cellular mechanotransduction, the process of translating mechanical forces into biological signals, is crucial for a wide range of physiological processes. A role for ion channels in sensing mechanical forces has been proposed for decades, but their identity in mammals remained largely elusive until the discovery of Piezos. Recent research on Piezos has underscored their importance in somatosensation (touch perception, proprioception and pulmonary respiration), red blood cell volume regulation, vascular physiology and various human genetic disorders.

中文翻译：

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压电在压力下壮成长：健康和疾病中的机械活化离子通道

细胞机械力转导是将机械力转化为生物信号的过程，对于广泛的生理过程至关重要。几十年来，人们已经提出了离子通道在感应机械力中的作用，但是直到发现Piezos之前，它们在哺乳动物中的身份仍然难以捉摸。对压电的最新研究强调了它们在躯体感觉（触摸知觉，本体感觉和肺呼吸），红细胞体积调节，血管生理学和各种人类遗传疾病中的重要性。