Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities,Journal of Natural Products

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Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-10-10 00:00:00 , DOI: 10.1021/acs.jnatprod.6b00878
Xu Pang ₁ , Jian-Yuan Zhao ₁ , Xiao-Mei Fang ₁ , Tao Zhang ₁ , De-Wu Zhang ₁ , Hong-Yu Liu ₁ , Jing Su ₁ , Shan Cen ₁ , Li-Yan Yu ₁

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Thirty-three metabolites including five phenalenone derivatives (1–5), seven cytochalasins (6–12), thirteen butenolides (13–25), and eight phenyl derivatives (26–33) were isolated from Aspergillus sp. CPCC 400735 cultured on rice. The structures of all compounds were elucidated by NMR, MS, and CD experiments, of which 1–5 (asperphenalenones A–E), 6 (aspochalasin R), and 13 (aspulvinone R) were identified as new compounds. Specifically, asperphenalenones A–E (1–5) represent an unusual structure composed of a linear diterpene derivative linked to a phenalenone derivative via a C–C bond. Compounds 1, 4, 10, and 26 exhibited anti-HIV activity with IC₅₀ values of 4.5, 2.4, 9.2, and 6.6 μM, respectively (lamivudine 0.1 μM; efavirenz, 0.4 × 10^–3 μM).

中文翻译：

植物内生真菌曲霉菌的代谢产物。CPCC 400735及其抗艾滋病毒活动

三十三个代谢物包括五phenalenone衍生物（1 - 5），七个细胞松弛素（6 - 12），13个丁烯羟酸内酯（13 - 25），和八个苯基衍生物（26 - 33）从分离曲霉属。在水稻上培养的CPCC 400735。所有化合物的结构经NMR，MS，和CD实验，其中阐明1 - 5（asperphenalenones A-E），6（aspochalasin R），和13（aspulvinone R）被确定为新的化合物。具体来说，阿斯非芬酮A–E（1 – 5）代表由线性二萜衍生物通过C–C键连接至菲拉烯酮衍生物组成的不寻常结构。化合物1，4，10，和26显示出抗HIV活性与IC _50个4.5，2.4，9.2和6.6μM，分别的值（拉米夫定0.1μM;依法韦仑，0.4×10 ^-3 μM）。

更新日期：2017-10-10

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