Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment,Chemical Reviews

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-10-09 00:00:00 , DOI: 10.1021/acs.chemrev.7b00094
Guoyou Huang _{1,

2} , Fei Li _{1,

2} , Xin Zhao ₃ , Yufei Ma _{1,

2} , Yuhui Li _{1,

2} , Min Lin _{1,

2} , Guorui Jin _{1,

2} , Tian Jian Lu _{2,

4} , Guy M Genin _{1,

2,

5,

6} , Feng Xu _{1,

2}

Affiliation

The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells but also as a source of three-dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large-scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell–microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever-shifting state of the art, and it highlights areas in which substantial potential and uncertainty remain.

中文翻译：

用于三维细胞微环境工程的功能和仿生材料

细胞微环境已成为发育、生理学和病理生理学中细胞行为和功能的关键决定因素。细胞微环境中的细胞外基质 (ECM) 不仅是细胞的结构基础，而且还是触发和调节细胞行为的三维 (3D) 生化和生物物理线索的来源。越来越多的证据表明，微环境的 3D 特征对于体内观察到的许多关键细胞反应的发展是必需的，这推动了用于工程 3D 细胞微环境的功能和仿生材料的发展激增。此类材料设计的进展改善了对 3D 细胞行为的控制，并推动了组织再生、体外组织模型、大规模细胞分化、免疫治疗和基因治疗领域的发展。然而，该领域仍处于起步阶段，关于细胞-微环境相互作用本质的发现继续颠覆该领域的许多早期进展。主要挑战仍然是剖析化学、结构、力学和电生理学在细胞微环境中的作用，以及理解和利用这些因素中周期性和漂移的作用。这篇综述概括了最新进展似乎与不断变化的技术水平的差距，并强调了仍然存在巨大潜力和不确定性的领域。

更新日期：2017-10-09

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