当前位置: X-MOL 学术Annu. Rev. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Unconventional or Preset αβ T Cells: Evolutionarily Conserved Tissue-Resident T Cells Recognizing Nonpeptidic Ligands
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-100616-060725
Francois Legoux 1 , Marion Salou 1 , Olivier Lantz 1, 2, 3
Affiliation  

A majority of T cells bearing the αβ T cell receptor (TCR) are specific for peptides bound to polymorphic classical major histocompatibility complex (MHC) molecules. Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class-Ib (MHC-Ib) molecules. These cells have been termed unconventional for decades, even though only the composite antigen is different from the one seen by classical T cells. Herein, we discuss the identity of these particular T cells in light of the coevolution of their TCR and MHC-Ib restricting elements. We examine their original thymic development: selection on hematopoietic cells leading to the acquisition of an original differentiation program. Most of these cells acquire memory cell features during thymic maturation and exhibit unique patterns of migration into peripheral nonlymphoid tissues to become tissue resident. Thus, these cells are termed preset T cells, as they also display a variety of effector functions. They may act as microbial or danger sentinels, fight microbes, or regulate tissue homeostasis.

中文翻译:


非常规或预设的αβT细胞:识别非肽配体的进化保守的组织常驻T细胞。

大部分带有αβT细胞受体(TCR)的T细胞对与多态性经典主要组织相容性复合物(MHC)分子结合的肽具有特异性。T细胞的较小子集对与非多态性MHC Ib类(MHC-Ib)分子相关的各种非肽配体具有反应性。即使只有复合抗原与经典T细胞所见的抗原不同,这些细胞也被称为非常规细胞数十年。在本文中,我们根据其TCR和MHC-Ib限制元件的共同进化来讨论这些特定T细胞的身份。我们检查了它们最初的胸腺发育:对造血细胞的选择导致了原始分化程序的获得。这些细胞中的大多数在胸腺成熟过程中具有记忆细胞特征,并表现出独特的迁移模式,可迁移到周围的非淋巴组织中,从而成为驻留组织。因此,这些细胞被称为预设T细胞,因为它们还显示出多种效应子功能。它们可能充当微生物或危险前哨,与微生物作战或调节组织稳态。

更新日期:2017-10-06
down
wechat
bug