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Cell Polarity in Yeast
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-100616-060856
Jian-Geng Chiou 1 , Mohan K Balasubramanian 2 , Daniel J Lew 1
Affiliation  

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in diverse organisms. Here we review findings from budding and fission yeasts that reveal both a conserved core polarity circuit and several adaptations that each organism exploits to fulfill the needs of its lifestyle. The core circuit involves positive feedback by local activation of Cdc42 to generate a cluster of concentrated GTP-Cdc42 at the membrane. Species-specific pathways regulate the timing of polarization during the cell cycle, as well as the location and number of polarity sites.

中文翻译:


 酵母细胞极性


以 Cdc42 GTPase 为中心的保守分子机制调节不同生物体中的细胞极性。在这里,我们回顾了芽殖酵母和裂殖酵母的研究结果,这些发现揭示了保守的核心极性电路和每种生物体用来满足其生活方式需求的几种适应性。核心电路涉及通过 Cdc42 的局部激活进行正反馈,以在膜上生成一簇浓缩的 GTP-Cdc42。物种特异性途径调节细胞周期中极化的时间以及极性位点的位置和数量。

更新日期:2017-10-06
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