Dysregulation of the T_h17/T_reg balance is a key driver of autoimmunity. A new study by Xu et al. (2017) has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews T_h17 differentiation to the T_reg lineage, which is protective against autoimmune inflammation.

中文翻译：

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免疫代谢的蓬勃发展世界：Th17细胞占据中心地位。

T _h 17 / T _reg平衡的失调是自身免疫的关键驱动因素。Xu等人的一项新研究。（2017）发现小分子抑制2-羟基戊二酸合成会使T _h 17分化偏向T _reg谱系，从而保护自身免疫炎症。