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The Burgeoning World of Immunometabolites: Th17 Cells Take Center Stage.
Cell Metabolism ( IF 27.7 ) Pub Date : 2017-Oct-03 , DOI: 10.1016/j.cmet.2017.09.014
Glenn R. Bantug , Christoph Hess

Dysregulation of the Th17/Treg balance is a key driver of autoimmunity. A new study by Xu et al. (2017) has revealed that small-molecule inhibition of 2-hydroxyglutarate synthesis skews Th17 differentiation to the Treg lineage, which is protective against autoimmune inflammation.

中文翻译:

免疫代谢的蓬勃发展世界:Th17细胞占据中心地位。

T h 17 / T reg平衡的失调是自身免疫的关键驱动因素。Xu等人的一项新研究。(2017)发现小分子抑制2-羟基戊二酸合成会使T h 17分化偏向T reg谱系,从而保护自身免疫炎症。
更新日期:2017-10-03
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