The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.

中文翻译：

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饮食中的碳水化合物会损害健康和促进死亡率。

这项名为PURE的前瞻性队列研究发现，来自18个国家的135,000多名参与者中，营养性碳水化合物会增加人类的死亡率，而膳食脂肪会降低其死亡率，这要求对当前的营养指南进行根本性的改变。动物模型的实验证据为模拟低碳水化合物或生酮饮食提供了增效的机理概念以及药理学选择。